The Next Generation in Synthetic Bone Graft Substitutes

CopiOs Bone Void Filler Sponge is a synthetic bone graft material consisting of mineralized, lyophilized collagen that has been formed into sponges of various sizes for surgical implantation.

System Features

CopiOs Sponge consists of calcium phosphate within lyophilized type I bovine collagen sponges. The sponges are approximately 67% mineral by weight. The sponges are sized in 1cc (1 x 2 x 0.5cm) and 5cc (2 x 5 x 0.5cm) volumes. When in contact with viable bone at the defect site, CopiOs Sponge will act as an osteoconductive scaffold for the growth of new bone. As new bone growth occurs, the scaffold is resorbed.

CopiOs Bone Void Filler Paste is a synthetic bone graft material with an optimal pH level for bone healing, and an abundance of localized soluble mineral ions to promote bone formation. The mineralized, lyophilized collagen particles are formed into compressed powder discs of various sizes. CopiOs Paste is mixed into a putty consistency prior to surgical implantation. CopiOs Paste consists of calcium phosphate within lyophilized type I bovine collagen and is approximately 67% mineral by weight. CopiOs Paste is provided in three sizes (1cc, 5cc, and10cc volumes). When in contact with viable bone at the defect site, CopiOs Paste will act as an osteoconductive scaffold for the growth of new bone. As new bone growth occurs, the scaffold is resorbed.

Optimal pH Level for Bone Healing

  • CopiOs Bone Void Filler is comprised of calcium phosphate, dibasic (DICAL), and highly purified Type I bovine collagen CopiOs Bone Void Filler provides a moderately acidic environment that promotes solubility of osteoinductive growth factors such as bone morphogenic proteins (BMPs)
  • More soluble BMPs may remain available for bone healing processes in the early stages of bone growth1
  • The concentration of soluble BMPs in calcium salt solution decreases substantially when hydroxyapatite (HA) or beta-tricalcium phosphate (ß-TCP) is present

Abundance of Localized Soluble Mineral Ions Promotes Bone Formation

  • DICAL provides significantly more calcium and phosphate ions at equilibrium than either ß-TCP or HA (Fig. 2)² 
  • Abundance of localized soluble calcium and phosphate ions promotes bone formation³

Specifications

Resources

Additional Information